Nowadays, marijuana is used for everything from relieving pain to aiding sleep. However, one of the most exceptional benefits of smoking marijuana is that it can also help with depression. Research shows that even just a couple of puffs of weed can help reduce symptoms of depression, as well as helping with anxiety and stress. So what are the best marijuana strains for depression?

All kinds of marijuana strains can help with the symptoms of depression in one way or another. Indica strains help calm the mind and ease your worries, helping counteract negative thoughts and moods. Sativa strains give you a burst of happiness and motivation that can help snap you out of a bad mental state. Hybrid strains give you a mix of both. Here are eight of the best marijuana strains for depression to try out for yourself.

1. After Chem

After Chem is a sativa-dominant hybrid made by crossing numerous Haze strains. If you’re looking for a potent strain that delivers a mix of mentally-stimulating effects and physically-relaxing qualities, then this is one of the best choices for you. It also has a sweet and earthy flavor that makes it a joy to inhale.

When you smoke After Chem, you’ll swiftly feel more happy, focused, and motivated. This is ideal for counteracting depression, especially as it can reduce your motivation and make it hard to focus on daily tasks. On top of that, the physical effects increase over time, making you feel much more relaxed and content.

2. Black Cherry Cheesecake

Black Cherry Cheesecake is the result of crossing Black Cherry Soda, Super Silver Haze, and Cheese strains. This indica-dominant hybrid can help you in many ways, from boosting your focus to delivering full-body relaxation. It also has an interesting scent and taste with fruity and cheesy tones.

The high you’ll get from Black Cherry Cheesecake starts with a sensational wave of euphoria. Your mind will be stimulated so you’ll feel more focused and creative. The strong physical effects soon take over, providing soothing waves all over your body until you just want to lay back and rest. It can help with depression as well as stress, pain, migraines, insomnia, and more.

Elvis strain

3. Elvis

Another one of the best marijuana strains for depression is Elvis. It’s a cross between AK-47 and The Pure, resulting in a sensational strain with a sativa to indica ratio of 75:25 and powerful THC levels. It might be a little hard-hitting for some users, but many will enjoy the strong relief it delivers for all kinds of symptoms.

Elvis helps with depression by inducing an incredibly happy mood as well as giving you a burst of motivation and creativity. You’ll find it much easier to handle tasks you usually wouldn’t have the motivation for, and it can also help relieve your body of pain. It also packs a sweet flavor that makes it easy to enjoy whether you’re smoking or vaping.

4. Fortune Cookies

Fortune Cookies is a fantastic hybrid strain that crosses two legendary strains- Girl Scout Cookies and OG Kush. As such, you get a combination of the highly uplifting effects of GSC and the deeply relaxing qualities of OG Kush. All of this, as well as a sweet and earthy flavor, makes it one of the best strains for depression.

Although Fortune Cookies is sativa-dominant, the relaxing effects are particularly noticeable. Along with a stimulating head high, Fortune Cookies thoroughly calms and soothes your body. This makes it great for counteracting negative moods as well as helping you sleep, both of which will help users with depression.

5. God Bud

God Bud is an indica-dominant hybrid made by crossing Hawaii and Purple Skunk. With moderate THC levels of 15-20%, God Bud delivers a high that’s both mentally uplifting and physically relaxing without being too overwhelming. This makes it a great pick for users who want to combat various symptoms without feeling out of commission.

As far as mental effects go, God Bud makes you feel highly euphoric and gives you a burst of focus and creative energy. The physical effects help soothe you of any pain, aches, strains, or tension while also making it easy to sleep. These effects can be great for depression, as well as helping with anxiety, stress, chronic pain, inflammation, insomnia, and various other ailments.

6. Grape Ape

If you’re looking for a tranquilizing indica-dominant strain, then Grape Ape is a great choice. Combining Mendocino Purps, Skunk, and Afghani leads to this fantastic strain that can help treat a variety of issues, including depression. It also packs a deliciously rich grape-like taste that makes it even more enjoyable.

Grape Ape is incredibly relaxing. Not only will it soothe your body of any pain, but it also calms your mind to relieve you of any stress or worries. This is perfect for users with depression as it’ll leave you in a carefree and tension-free state. You’ll feel warm, content, and ready to sleep under the influence of this strain.

Lemon Haze

7. Lemon Haze

If you enjoy fruity strains with uplifting effects, Lemon Haze is one of the best strains you can buy. It’s known for its zesty citrus scent and taste, making it a pleasure to vape or smoke. However, on top of its delicious flavor, Lemon Haze also offers one of the most enjoyable highs.

Lemon Haze makes you feel exceptionally happy and euphoric. If you’re looking for a strain that can swiftly counteract the negative mood brought by depression, this is perfect. Taking a few more hits will bring out more of its relaxing qualities- helping you feel calm and mellow and helping with symptoms of pain, stress, and insomnia.

8. Nuken

Nuken is one of the best strains out there for users who want mellow relaxation without feeling too overwhelmed. It’s an indica-dominant strain made by combining God Bud and Kish. With a ratio of 80:20 indica to sativa, it provides an uplifting mental burst along with deeply relaxing physical effects.

This strain is great for using in the evening as it’ll make you feel incredibly calm. It releases any anxiety or worries from your mind while also thoroughly soothing your body. Whether you’re looking to counteract the symptoms of depression or need something to help with pain, stress, and sleep, Nuken is a top choice.


All kinds of marijuana strains can help with the symptoms of depression in one way or another. Make sure you smoke in a safe and comfortable environment when you have the time and you should have a highly positive experience. Of course, it also helps to buy high-quality weed from a trusted source. You can find plenty of premium strains of weed and various other marijuana products online from Leaf2Go Online Dispensary.